+82-2-6490-5625
Cellular Signal Transduction Lab.
University of Seoul
In our lab, we focus on elucidating the mechanisms behind how Wnt and Hippo signaling pathways are regulated to discover therapeutic targets of the diseases caused by abnormal regulation of these pathways.
Wnt and Hippo signaling pathways were first studied as factors that take part in cancer development, early development of the body, or as a mechanism regulating organ size. Nowadays, as it was also found to have connections with apoptosis, NF-κB signaling, synaptogenesis, embryonic stem cell maintenance/differentiation, as well as Alzheimer’s disease, the fields of Wnt/Hippo signaling pathway are being studied with utmost attention around the world.
We conduct experiments not only to clarify the regulatory mechanisms of Wnt and Hippo signaling pathways but also to broaden our view on involvement of these pathways to cancer development, regulation of embryonic stemness/ differentiation, and Alzheimer’s disease, using molecular biological techniques, mouse embryonic stem cells, primary neural cultures, organoids and transgenic mice etc.
PROFESSOR
조 익 훈 (Eek-hoon Jho)
Education:
Seoul National University (Seoul, Korea)
B.S. 1986 Agri-chemistry
Hanyang University (Seoul, Korea)
M.S. 1989 Genetic Engineering
Michigan State University (E. Lansing)
Ph.D. 1995 Molecular biology
Experiences:
Michigan State University 1990.9 - 1995.10 Teaching Assistant
SUNY at Stony Brook 1995.11 - 1997.2 Post-doctoral Research Scientist
Columbia University (New York) 1997.3 - 2000.12 Associate Research Scientist
The University of Seoul 2001.9 – present Professor
University of Southern California 2007.12-2008.12 Visiting Scholar
LATEST PUBLICATION
2023
Thao Thi Dang, Mi-Jeong Kim, Yoon Young Lee, Hien Thi Le, Kook Hwan Kim, Somi Nam, Seung Hwa Hyun, Hong Lim Kim, Su Wol Chung, Hun Taeg Chung, Jho EH, Hiderou Yoshida, Kyoungmi Kim, Chan Young Park, Myung-Shik Lee, Sung Hoon Back. Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress. Autophagy. 2023 Jan 31. doi: 10.1080/15548627.2023.2173900. Online ahead of print.
2022
Lee J, Kim E, Kang MK, Ryu J, Kim JE, Shin EA, Pinanga Y, Pyo KH, Lee H, Lee EH, Cho H, Cheon J, Kim W, Jho EH, Kim S, Lee JW. Systemic TM4SF5 overexpression in Apc Min/+ mice promotes hepatic portal hypertension associated with fibrosis. BMB Rep. 2022 Dec;55(12):609-614. doi: 10.5483/BMBRep.2022.55.12.104.
Kim E, Kang JG, Jho EH, Yang WH, Cho JW. O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway. Cancers (Basel). 2022 Jun 18;14(12):3013. doi: 10.3390/cancers14123013.
Tan A*, Prasad R*, Lee C, and Jho EH. Past, Present, and Future Perspectives of Transcription Factor EB (TFEB): Mechanisms of regulation and association with disease. Cell Death Differ. 2022 Aug;29(8):1433-1449. doi: 10.1038/s41418-022-01028-6.
Lee U, Cho E, Jho EH. Regulation of Hippo signaling by metabolic pathways in cancer. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119201. doi: 10.1016/j.bbamcr.2021.119201.
2021
Prasad R, Jung W, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, and Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in the patients of Alzheimer’s disease. Scientific Rep. 2021 Oct 8;11(1):20075. doi: 10.1038/s41598-021-99562-9.
Jeong W, Jho EH. Regulation of the low-density lipoprotein receptor-related protein LRP6 and its association with disease: Wnt/β-catenin signaling and beyond. Front. Cell Dev. Biol. 2021 Sep 13;9:714330. doi: 10.3389/fcell.2021.714330 eCollection 2021.
Kwon H, Kim J, Jho EH. Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ. FEBS J. 2022 Oct;289(19):5798-5818.
2021 Jun 26. doi: 10.1111/febs.16091.
Tan A, Prasad R and Jho EH. TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy-lysosomal Biogenesis. Cell Death Dis.2021 Apr 1;12(4):343. doi: 10.1038/s41419-021-03632-9.
● This work has been selected by "CDDpress: Our Monthly Top Picks"
Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH . PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. Cell Death Differ. 2021 Sep;28(9):2555-2570. doi: 10.1038/s41418-021-00770-7.
Jang J, Song J, Lee H, Sim I, Kwon YV, Jho EH*, and Yoon Y*. LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways. Exp Mol Med. 2021 Mar;53(3):407-421. doi: 10.1038/s12276-021-00577-z. (*, Co-corresponding authors.)
Kwon O, Song J, Yang Y, Kim S, Kim J, Seok M, Hwang I, Yu J, Jenisha K, Maeng H, Kim J, Jho EH, Ko S, Ko S, Son H, Chang M, Lee S. SGK1 inhibition in glia ameliorates pathologies and symptoms of Parkinson's disease. EMBO Mol Med. 2021 Apr 9;13(4):e13076. doi: 10.15252/emmm.202013076.
2020
Lee EJ, Seo E, Kim JW, Nam SA, Lee JY, Jun J, Oh S, Park M, Jho EH, Yoo KH, Park JH, Kim YK. (2020) TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 117(46):29001-29012.
Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH. 2020. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103
● A commentary for this work was presented in “News & Views” in EMBO reports.
● This work has been recommended in Faculty Opinions.
Kim S, Kim H, Tan A, Song Y, Lee H, Ying QL, Jho EH. 2020. The distinct role of Tcfs and Lef1 in the self-renewal or differentiation of mouse embryonic stem cells. Int J Stem Cells. 13(2):192-201.
Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W*, Jho EH*. 2020. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540. (*, Co-corresponding authors)
Kim E, Kang JG, Kang MJ, Park JH, Kim YJ, Kim Y, Kweon TH, Lee HW, Jho EH, Lee Y, Kim SI, Yi EC, Park HW, Yang WH, Cho JW. 2020. O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity. Proc Natl Acad Sci U S A. 117(25):1459-14269.
Contact
Eek-hoon Jho, Ph.D.
Department of Life Science
University of Seoul
163 Seoulsiripdae-ro, Dongdaemoon-gu, Seoul, 02504 KOREA
Tel: 82-2-6490-2671(Office), 5625(Lab)
E-mail. ej70@uos.ac.kr